Endocrine Abstracts

Background: Pituitary adenomas (PA) and pheochromocytomas/paraganglioma (pheo/PGL) can occur in the same patient due to coincidence or of shared pathogenesis. There is evidence that, at least in some cases, classical pheo/PGL predisposing genes, may also play a role in pituitary tumorigenesis. A new condition called ‘the three P Association’ (3PAs) for the combination of PA with pheo/PGL has been recently described in patients with or without succinate dehydrogenase ...

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumour. At diagnosis 21% has metastasis. Even after complete surgical removal, patients are at risk of recurrence as late as 10-12 years. The 5-year survival rate of Stage I to IV (ENSAT 2008) is 82%, 61%, 50% and 13% respectively.Objetive: To describe the epidemiological and clinical characteristics, as well as the evolution, treatments and overall survival of patients diagnosed with ...

Purpose: The aim of this study was to evaluate the sensitivy of contrast-enhanced ultrasound (CEUS) in the detection of pathological parathyroid gland in patients with primary hyperparathyroidism in comparison to the 99m-MIBI-SPECT scintigraphy.Methods: 29 patients consecutive (22 female, 7 male) with biochemically confirmed primary hyperparathyroidism, who underwent preoperative imaging with Technetium 99m-MIBI-SPECT scintigraphy and CEUS and subsequent...

Background: Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PCC/PGL) are the main components of MEN1 and MEN2, respectively. Although the presence of both tumors (3P association, 3PAs) in the same patient could be as a result of coincidence, at least in some cases, a common pathogenic mechanism has been involved. Recently has been confirmed that germline mutations in genes coding succinate dehydrogenase (SDH) play a role in pituitary tumorigenesis. Furthermore, M...

Introduction: Primary aldosteronism (PA) is the most common cause of secondary hypertension. Guidelines recommend a confirmatory test in the majority of suspected cases: oral sodium loading, saline infusion test (SIT), captopril challenge test (CCT), or fludrocortisone suppression test. The SIT and CCT are most commonly used in clinical practice to study autonomous aldosterone secretion.Objectives and Methods: We compared the CCT’s diagnosis perform...